Journal article
A genome-wide association study of IVGTT-based measures of first phase insulin secretion refines the underlying physiology of Type 2 Diabetes variants.
- Abstract:
-
Understanding the physiological mechanisms by which common variants predispose to type 2 diabetes requires large studies with detailed measures of insulin secretion and sensitivity. Here we performed the largest genome-wide association study of first phase insulin secretion, as measured by intravenous glucose tolerance tests, using up to 5,567 non-diabetic individuals from 10 studies. We aimed to refine the mechanisms of 178 known associations between common variants and glycaemic traits a...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
+ Netherlands Organization for Scientific Research
More from this funder
Grant:
NWO/SPI 56-464-14192
Bibliographic Details
- Publisher:
- American Diabetes Association Publisher's website
- Journal:
- Diabetes Journal website
- Publication date:
- 2017-05-01
- DOI:
- EISSN:
-
1939-327X
- ISSN:
-
0012-1797
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:695826
- UUID:
-
uuid:43c4e279-7587-49fe-93d3-d736b91add4e
- Local pid:
- pubs:695826
- Source identifiers:
-
695826
- Deposit date:
- 2017-05-24
Terms of use
- Copyright holder:
- American Diabetes Association
- Copyright date:
- 2017
- Notes:
- © 2017 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license.
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