Thesis
Computational methods for the study of immunoglobulin aggregation
- Abstract:
-
Protein aggregation is a major challenge in the development of antibody-based therapeutics. Therapeutic antibodies are produced and stored in high concentrations and under fluctuating conditions unfavourable for their stability. Aggregation of these proteins in solution leads to serious consequences for patients, with the initiation of immune reactions, which have the potential to be fatal, and in the loss of clinical potency. The types of aggregates formed by antibodies, and the processes...
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Authors
Contributors
+ Sansom, M
Division:
MSD
Department:
Biochemistry
Role:
Supervisor
+ Gallagher, T
Division:
MSD
Department:
Biochemistry
Role:
Supervisor
Funding
+ Biotechnology and Biological Sciences Research Council
More from this funder
Funding agency for:
Shorthouse, D
Bibliographic Details
- Publication date:
- 2015
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:43c0950e-7f58-48b9-899d-74dcfee35887
- Local pid:
- ora:10826
- Deposit date:
- 2015-04-07
Terms of use
- Copyright holder:
- Shorthouse, D
- Copyright date:
- 2014
- Notes:
- This thesis is not currently available in ORA.
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