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The MAPK pathway regulates intrinsic resistance to BET inhibitors in colorectal cancer.

Abstract:

The bromodomain and extra-terminal domain (BET) family proteins are epigenetic readers for acetylated histone marks. Emerging BET bromodomain inhibitors have exhibited antineoplastic activities in a wide range of human cancers through suppression of oncogenic transcription factors, including MYC. However, the preclinical activities of BET inhibitors in advanced solid cancers are moderate at best. To improve BET-targeted therapy, we interrogated mechanisms mediating resistance to BET inhibitor...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1158/1078-0432.CCR-16-0453

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Publisher:
American Association for Cancer Research Publisher's website
Journal:
Clinical Cancer Research Journal website
Volume:
23
Issue:
8
Pages:
2027-2037
Publication date:
2016-09-27
Acceptance date:
2016-09-14
DOI:
ISSN:
1078-0432 and 1557-3265
Pmid:
27678457
Source identifiers:
648037
Language:
English
Keywords:
Pubs id:
pubs:648037
UUID:
uuid:43a93e60-cbfe-4b80-b613-40450f0f3b7c
Local pid:
pubs:648037
Deposit date:
2016-11-11

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