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Thesis

Isolation of Fibrillar Elastin Gel (FEG) and its application in heart valve tissue engineering

Abstract:

Elastin, although a small constituent of heart valves, plays a significant role in its functionality and the maintenance of tissue homeostasis. It is due to its low abundance that its significance has been overlooked in favour of collagen and glycosaminoglycans. However, repeatedly, the failure of biological prostheses has been associated with the disruption of elastic fibres. The incorporation of exogenous forms of elastin has been challenging due to the intrinsic insolubility and poor pr...

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Institution:
University of Oxford
Division:
MPLS
Department:
Materials
Sub department:
Materials
Research group:
Biomaterials
Oxford college:
Linacre College
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MPLS
Department:
Materials
Sub department:
Materials
Research group:
Biomaterials
Oxford college:
Trinity College
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
Deposit date:
2021-07-27

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