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Pain in knee osteoarthritis is associated with variation in the neurokinin 1/substance P receptor (TACR1) gene

Abstract:

Background: Substance P (SP) is a pain- and inflammation-related neuropeptide which preferentially binds to the neurokinin receptor 1 (NK1). SP and NK1 receptors have been implicated in joint pain, inflammation and damage in animal models and human studies of osteoarthritis (OA). The aim of this study was to test if genetic variation at the neurokinin 1 receptor gene (TACR1) is associated with pain in individuals with radiographic knee OA.

Methods: Participants from the Genetics o...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/ejp.1027

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
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Funding agency for:
Laslett, L
Grant:
GNT1070586
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Funding agency for:
Valdes, A
Grant:
108239
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Publisher:
Wiley Publisher's website
Journal:
European Journal of Pain Journal website
Volume:
21
Issue:
7
Pages:
1277-1284
Publication date:
2017-07-13
Acceptance date:
2017-01-21
DOI:
EISSN:
1532-2149
ISSN:
1090-3801
Source identifiers:
724270
Pubs id:
pubs:724270
UUID:
uuid:42f7cf9a-918a-4459-85e0-a1839be52f55
Local pid:
pubs:724270
Deposit date:
2017-08-25

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