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Journal article

The importance of early immunotherapy in 103 patients with faciobrachial dystonic seizures

Abstract:

Faciobrachial dystonic seizures (FBDS) and limbic encephalitis closely associate with LGI1- antibodies. Here, we describe 103 consecutive patients with FBDS and LGI1-antibodies to understand clinical, therapeutic and serological differences between those with and without cognitive impairment (CI), and to determine whether cessation of FBDS can prevent CI. The 22/103 patients without CI typically had normal brain imaging, EEGs, sodium levels (p<0·0001) and almost exclusive IgG4 LGI1-antibod...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/brain/awx323

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
Expand authors...
Wellcome Trust More from this funder
Epilepsy Research UK More from this funder
BMA Research Grant More from this funder
Fulbright UK-US Commission More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Brain Journal website
Volume:
141
Issue:
2
Pages:
348–356
Publication date:
2017-12-18
Acceptance date:
2017-10-17
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
Keywords:
Pubs id:
pubs:743441
UUID:
uuid:42990a4e-23be-4e55-aa8a-12f8321742dd
Local pid:
pubs:743441
Deposit date:
2017-11-04

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