Journal article
How to maintain the maximal level of blinding in randomisation for a placebo-controlled drug trial
- Abstract:
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We illustrate the approach of randomising treatments and compare it with the traditional approach of randomising patients, using a case study drawn from the authors’ experience in clinical trials. The setting is a double-blind parallel two-arm randomised controlled trial (RCT), but the method in this paper can be extended to single-blind, cross-over, or multi-arm RCTs. We propose the concept of two different levels of blinding: full blinding and partial blinding. We subsequently show how to ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 208.4KB)
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- Publisher copy:
- 10.1016/j.conctc.2019.100356
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Authors
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Contemporary Clinical Trials Communications Journal website
- Volume:
- 14
- Article number:
- 100356
- Publication date:
- 2019-04-09
- Acceptance date:
- 2019-04-05
- DOI:
- ISSN:
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2451-8654
- Source identifiers:
-
992884
Item Description
- Keywords:
- Pubs id:
-
pubs:992884
- UUID:
-
uuid:4230d82c-2bd4-45a8-90aa-ef042100adb6
- Local pid:
- pubs:992884
- Deposit date:
- 2019-04-25
Terms of use
- Copyright holder:
- Clifton and Clifton
- Copyright date:
- 2019
- Notes:
- © 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/).
- Licence:
- CC Attribution (CC BY)
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