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Hyaluronan derived from the limbus is a key Regulator of Corneal Lymphangiogenesis

Abstract:

Purpose:
Corneal lymphangiogenesis and angiogenesis leads to the loss of corneal transparency. We have recently shown that in the cornea hyaluronan (HA) is present primarily in the limbal region and plays a key role regulating the limbal stem cell phenotype. Given the HA receptor LYVE-1 is highly expressed in corneal lymphatic vessels we investigated whether HA could play a role in regulating corneal lymphangiogenesis.

Methods:
Wild-type (wt) and hyaluronan synthase (HAS) kno...

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Publication status:
Published
Peer review status:
Reviewed (other)

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Publisher:
Association for Research in Vision and Ophthalmology Publisher's website
Journal:
Investigative Ophthalmology and Visual Science Journal website
Volume:
61
Issue:
7
Host title:
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
Publication date:
2020-06-01
EISSN:
1552-5783
ISSN:
0146-0404
Language:
English
Keywords:
Pubs id:
1131046
Local pid:
pubs:1131046
Deposit date:
2020-10-01

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