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MAIT cells contribute to protection against lethal influenza infection in vivo

Abstract:

Mucosal associated invariant T (MAIT) cells are evolutionarily-conserved, innate-like lymphocytes which are abundant in human lungs and can contribute to protection against pulmonary bacterial infection. MAIT cells are also activated during human viral infections, yet it remains unknown whether MAIT cells play a significant protective or even detrimental role during viral infections in vivo. Using murine experimental challenge with two strains of influenza A virus, we show that MAIT cells acc...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-018-07207-9

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Role:
Author
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Funding agency for:
Van Wilgenburg, B
Grant:
IE160540
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Funding agency for:
Klenerman, P
Grant:
Senior Fellowship, Oxford Martin School
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Funding agency for:
Klenerman, P
Grant:
Senior Fellowship, Oxford Martin School
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Funding agency for:
Hinks, T
Grant:
Postdoctoral Research Fellowship
104553/z/14/z
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Article number:
4706
Publication date:
2018-11-09
Acceptance date:
2018-10-16
DOI:
EISSN:
2041-1723
Keywords:
Pubs id:
pubs:927658
UUID:
uuid:4218fa55-3efa-474b-abef-ecc18618ac5c
Local pid:
pubs:927658
Deposit date:
2018-10-16

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