Journal article
Determination of an optimally sensitive and specific Chemical Exchange Saturation Transfer MRI quantification metric in relevant biological phantoms
- Abstract:
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The purpose of this study was to develop realistic phantom models of the intracellular environment of metastatic breast tumour and naïve brain, and using these models determine an analysis metric for quantification of CEST-MRI data which is sensitive to only labile proton exchange rate and concentration. The ability of the optimal metric to quantify pH differences in the phantoms was also evaluated.
Novel phantom models were produced, by adding perchloric acid extracts of eith...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.1MB)
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- Publisher copy:
- 10.1002/nbm.3614
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Authors
Funding
+ Biotechnology and Biological Sciences Research Council
More from this funder
Funding agency for:
Baldwin, A
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Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- NMR in Biomedicine Journal website
- Volume:
- 29
- Issue:
- 11
- Pages:
- 1624–1633
- Publication date:
- 2016-09-01
- Acceptance date:
- 2016-08-04
- DOI:
- EISSN:
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1099-1492
- ISSN:
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0952-3480
- Source identifiers:
-
637475
Item Description
- Keywords:
- Pubs id:
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pubs:637475
- UUID:
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uuid:41926794-54fb-4a3c-97dd-bf56ed89590d
- Local pid:
- pubs:637475
- Deposit date:
- 2016-08-05
Terms of use
- Copyright holder:
- Baldwin et al
- Copyright date:
- 2016
- Notes:
- © 2016 The Authors NMR in Biomedicine Published by John Wiley and Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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