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Determination of an optimally sensitive and specific Chemical Exchange Saturation Transfer MRI quantification metric in relevant biological phantoms

Abstract:

The purpose of this study was to develop realistic phantom models of the intracellular environment of metastatic breast tumour and naïve brain, and using these models determine an analysis metric for quantification of CEST-MRI data which is sensitive to only labile proton exchange rate and concentration. The ability of the optimal metric to quantify pH differences in the phantoms was also evaluated.


Novel phantom models were produced, by adding perchloric acid extracts of eith...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/nbm.3614

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Institution:
University of Oxford
Oxford college:
Pembroke College
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
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Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Role:
Author
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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Physical & Theoretical Chem
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Physical & Theoretical Chem
Role:
Author
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More from this funder
Funding agency for:
Ray, K
Grant:
MC_ST_U13080
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Publisher:
Wiley Publisher's website
Journal:
NMR in Biomedicine Journal website
Volume:
29
Issue:
11
Pages:
1624–1633
Publication date:
2016-09-01
Acceptance date:
2016-08-04
DOI:
EISSN:
1099-1492
ISSN:
0952-3480
Source identifiers:
637475
Keywords:
Pubs id:
pubs:637475
UUID:
uuid:41926794-54fb-4a3c-97dd-bf56ed89590d
Local pid:
pubs:637475
Deposit date:
2016-08-05

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