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Hypoxia-induced damage in human islets is reduced with the use of mesenchymal stem cell-preconditioned medium

Abstract:

Mesenchymal stem cells (MSCs) are protective for islets when cotransplanted in a hypoxic environment. However, the risk of neoplasia is increased when MSCs are transplanted into immunosuppressed patients. This initial study aimed to investigate whether the production of protective factors from MSC can be stimulated by different culture conditions to benefit human islets cultured in hypoxia.MSC were isolated from human adipose tissue and cultured for 2 days in supplemented Minimum Essential Me...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Surgical Sciences
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Surgical Sciences
Role:
Author
ORCID:
0000-0001-5117-4447
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Surgical Sciences
Role:
Author
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Publisher:
Elsevier Publisher's website
Journal:
Transplantation Proceedings Journal website
Volume:
49
Issue:
10
Pages:
2330-2332
Publication date:
2017-12-01
DOI:
EISSN:
1873-2623
ISSN:
0041-1345
Pmid:
29198672
Source identifiers:
811140
Language:
English
Keywords:
Pubs id:
pubs:811140
UUID:
uuid:416318a5-f417-40f0-ade5-af6fe7f60822
Local pid:
pubs:811140
Deposit date:
2018-04-12

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