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Structural and biophysical analysis of nuclease protein antibiotics

Abstract:

Protein antibiotics (bacteriocins) are a large and diverse family of multidomain toxins that kill specific Gram-negative bacteria during intraspecies competition for resources. Our understanding of the mechanism of import of such potent toxins has increased significantly in recent years, especially with the reporting of several structures of bacteriocin domains. Less well understood is the structural biochemistry of intact bacteriocins and how these compare across bacterial species. Here, we ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1042/BCJ20160544

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
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Funding agency for:
McCaughey, L
Grant:
093592/Z/10/Z
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Funding agency for:
Kleanthous, K
Grant:
BB/G020671/1
Publisher:
Portland Press Publisher's website
Journal:
Biochemical Journal Journal website
Volume:
473
Issue:
18
Pages:
2799-2812
Publication date:
2016-09-12
Acceptance date:
2016-07-07
DOI:
EISSN:
1470-8728
ISSN:
0264-6021
Source identifiers:
632382
Keywords:
Pubs id:
pubs:632382
UUID:
uuid:411c3453-8106-4861-b565-4714e71a9ed7
Local pid:
pubs:632382
Deposit date:
2016-07-07

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