Journal article
HLA-DM stabilizes the empty MHCII binding groove: a model using customized Natural Move Monte Carlo
- Abstract:
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MHC class II molecules bind peptides derived from extracellular proteins that have been ingested by antigen-presenting cells and display them to the immune system. Peptide loading occurs within the antigen-presenting cell and is facilitated by HLA-DM. HLA-DM stabilises the open conformation of the MHCII binding groove when no peptide is bound. While a structure of the MHCII/HLA-DM complex exists, the mechanism of stabilisation is still largely unknown. Here, we applied customised Natural Move...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.7MB)
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- Publisher copy:
- 10.1021/acs.jcim.9b00104
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Authors
Bibliographic Details
- Publisher:
- American Chemical Society Publisher's website
- Journal:
- Journal of Chemical Information and Modeling Journal website
- Volume:
- 59
- Issue:
- 6
- Pages:
- 2894-2899
- Publication date:
- 2019-05-09
- DOI:
- EISSN:
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1549-960X
- ISSN:
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1549-9596
- Pmid:
-
31070900
- Source identifiers:
-
1000251
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:1000251
- UUID:
-
uuid:40f8786f-5d71-4d18-9f4f-87faa04225f3
- Local pid:
- pubs:1000251
- Deposit date:
- 2019-05-25
Terms of use
- Copyright holder:
- American Chemical Society
- Copyright date:
- 2019
- Notes:
- © American Chemical Society. This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
- Licence:
- CC Attribution (CC BY)
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