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Journal article

HLA-DM stabilizes the empty MHCII binding groove: a model using customized Natural Move Monte Carlo

Abstract:

MHC class II molecules bind peptides derived from extracellular proteins that have been ingested by antigen-presenting cells and display them to the immune system. Peptide loading occurs within the antigen-presenting cell and is facilitated by HLA-DM. HLA-DM stabilises the open conformation of the MHCII binding groove when no peptide is bound. While a structure of the MHCII/HLA-DM complex exists, the mechanism of stabilisation is still largely unknown. Here, we applied customised Natural Move...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/acs.jcim.9b00104

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Institution:
University of Oxford
Division:
MPLS
Department:
Statistics
Oxford college:
Kellogg College
Role:
Author
ORCID:
0000-0003-1388-2252
Publisher:
American Chemical Society Publisher's website
Journal:
Journal of Chemical Information and Modeling Journal website
Volume:
59
Issue:
6
Pages:
2894-2899
Publication date:
2019-05-09
DOI:
EISSN:
1549-960X
ISSN:
1549-9596
Pmid:
31070900
Source identifiers:
1000251
Language:
English
Keywords:
Pubs id:
pubs:1000251
UUID:
uuid:40f8786f-5d71-4d18-9f4f-87faa04225f3
Local pid:
pubs:1000251
Deposit date:
2019-05-25

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