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Thesis

The histone deacetylase inhibitor panobinostat as a radiosensitiser in bladder cancer

Abstract:

Muscle invasive bladder cancer (MIBC) has a poor prognosis. Currently, therapy consists of radical radiotherapy or cystectomy with or without chemotherapy. The average age of patients with MIBC is high and older patients are less able to tolerate surgery or chemoradiation due to their impaired physical fitness and generally poor renal function. There is an urgent need to find new treatment regimes that are both tolerable and effective.

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Oxford college:
Wolfson College
Role:
Author

Contributors

Division:
MSD
Department:
Oncology
Role:
Supervisor
Division:
MSD
Department:
Oncology
Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:40f48d00-8d74-41db-8630-ceacf22f3e78
Local pid:
ora:9789
Deposit date:
2015-01-22

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