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Journal article

Potential impact of individual exposure histories to endemic human coronaviruses on age-dependent severity of COVID-19

Abstract:

Background

Cross-reactivity to SARS-CoV-2 from exposure to endemic human coronaviruses (eHCoV) is gaining increasing attention as a possible driver of both protection against infection and COVID-19 severity. Here we explore the potential role of cross-reactivity induced by eHCoVs on age-specific COVID-19 severity in a mathematical model of eHCoV and SARS-CoV-2 transmission.

Methods

We use an individual-based model, calibrated to prior...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1186/s12916-020-01887-1

Authors


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Georg and Emily Von Opel Foundation More from this funder
Publisher:
BMC Publisher's website
Journal:
BMC Medicine Journal website
Volume:
19
Issue:
1
Article number:
19
Publication date:
2021-01-12
Acceptance date:
2020-12-11
DOI:
EISSN:
1741-7015
Language:
English
Keywords:
Pubs id:
1151999
Local pid:
pubs:1151999
Deposit date:
2021-01-04

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