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Iterative arylation of amino acids and aliphatic amines via δ‐C(sp3)−H activation: experimental and computational exploration

Abstract:

Directed C-H functionalization has been realized as a complementary tool to the traditional approaches for a straightforward access of non-proteinogenic amino acids; albeit such a process is restricted mostly up to the γ-position. In the present work, we demonstrate the diversification [(hetero)arylation] of amino acids and analogous aliphatic amines selectively at the remote δ-position by tuning the reactivity controlled by ligands. An organopalladium δ-C(sp3)-H activated intermediate has be...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/anie.201900479

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Chemistry Research Laboratory
Role:
Author
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Publisher:
Wiley Publisher's website
Journal:
Angewandte Chemie International Edition Journal website
Volume:
58
Issue:
17
Pages:
5633-5638
Publication date:
2019-03-21
Acceptance date:
2019-02-28
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
Pmid:
30821038
Source identifiers:
980698
Language:
English
Keywords:
Pubs id:
pubs:980698
UUID:
uuid:408f6039-ba05-4c6f-8314-fe3be346125f
Local pid:
pubs:980698
Deposit date:
2019-03-15

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