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CDH6 and HAGH protein levels in plasma associate with Alzheimer’s disease in APOE ε4 carriers

Abstract:

Many Alzheimer’s disease (AD) genes including Apolipoprotein E (APOE) are found to be expressed in blood-derived macrophages and thus may alter blood protein levels. We measured 91 neuro-proteins in plasma from 316 participants of the Rotterdam Study (incident AD = 161) using Proximity Extension Ligation assay. We studied the association of plasma proteins with AD in the overall sample and stratified by APOE. Findings from the Rotterdam study were replicated in 186 AD patients of the BioFINDE...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41598-020-65038-5

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Role:
Author
ORCID:
0000-0002-8658-3790
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Role:
Author
ORCID:
0000-0003-2808-3699
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Role:
Author
ORCID:
0000-0001-8467-7286
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Role:
Author
ORCID:
0000-0003-2633-2495
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Publisher:
Springer Nature Publisher's website
Journal:
Scientific Reports Journal website
Volume:
10
Issue:
1
Article number:
8233
Publication date:
2020-05-19
Acceptance date:
2020-04-24
DOI:
EISSN:
2045-2322
Pmid:
32427856
Language:
English
Keywords:
Pubs id:
1106501
Local pid:
pubs:1106501
Deposit date:
2020-07-28

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