Journal article
CDH6 and HAGH protein levels in plasma associate with Alzheimer’s disease in APOE ε4 carriers
- Abstract:
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Many Alzheimer’s disease (AD) genes including Apolipoprotein E (APOE) are found to be expressed in blood-derived macrophages and thus may alter blood protein levels. We measured 91 neuro-proteins in plasma from 316 participants of the Rotterdam Study (incident AD = 161) using Proximity Extension Ligation assay. We studied the association of plasma proteins with AD in the overall sample and stratified by APOE. Findings from the Rotterdam study were replicated in 186 AD patients of the BioFINDE...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, 2.4MB)
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- Publisher copy:
- 10.1038/s41598-020-65038-5
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Authors
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Scientific Reports Journal website
- Volume:
- 10
- Issue:
- 1
- Article number:
- 8233
- Publication date:
- 2020-05-19
- Acceptance date:
- 2020-04-24
- DOI:
- EISSN:
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2045-2322
- Pmid:
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32427856
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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1106501
- Local pid:
- pubs:1106501
- Deposit date:
- 2020-07-28
Terms of use
- Copyright holder:
- Ahmad, S et al.
- Copyright date:
- 2020
- Rights statement:
- © The Author(s) 2020. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
- Licence:
- CC Attribution (CC BY)
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