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High-throughput crystallography reveals boron-containing inhibitors of a penicillin-binding protein with di- and tricovalent binding modes

Abstract:

The effectiveness of β-lactam antibiotics is increasingly compromised by β-lactamases. Boron-containing inhibitors are potent serine-β-lactamase inhibitors, but the interactions of boron-based compounds with the penicillin-binding protein (PBP) β-lactam targets have not been extensively studied. We used high-throughput X-ray crystallography to explore reactions of a boron-containing fragment set with the Pseudomonas aeruginosa PBP3 (PaPBP3). Multiple crystal structures reveal that boronic aci...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/acs.jmedchem.1c00717

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Role:
Author
ORCID:
0000-0001-7822-1944
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Publisher:
American Chemical Society Publisher's website
Journal:
Journal of Medicinal Chemistry Journal website
Volume:
64
Issue:
15
Pages:
11379-11394
Place of publication:
United States
Publication date:
2021-07-31
Acceptance date:
2020-10-30
DOI:
EISSN:
1520-4804
ISSN:
0022-2623
Pmid:
34337941
Language:
English
Keywords:
Pubs id:
1189500
Local pid:
pubs:1189500
Deposit date:
2021-09-17

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