Journal article
Variable regions of antibodies and T-cell receptors may not be sufficient in molecular simulations investigating binding.
- Abstract:
-
Antibodies and T-cell receptors are important proteins of the immune system that share similar structures. Both contain variable and constant regions. Insight into the dynamics of their binding can be provided by computational simulations. For these simulations the constant regions are often removed to save runtime as binding occurs in the variable regions. Here we present the first study to investigate the effect of removing the constant regions from antibodies and T-cell receptors on such s...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Roche
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Bibliographic Details
- Publisher:
- American Chemical Society Publisher's website
- Journal:
- Journal of Chemical Theory and Computation Journal website
- Volume:
- 13
- Issue:
- 7
- Pages:
- 3097–3105
- Publication date:
- 2017-06-01
- Acceptance date:
- 2017-06-14
- DOI:
- EISSN:
-
1549-9626
- ISSN:
-
1549-9618
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:719276
- UUID:
-
uuid:3ffd7ee5-1194-40b6-aabb-b7ef11576cf5
- Local pid:
- pubs:719276
- Source identifiers:
-
702414
- Deposit date:
- 2017-07-10
Terms of use
- Copyright holder:
- American Chemical Society
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 American Chemical Society. This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
- Licence:
- CC Attribution (CC BY)
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