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Differential and interactive effects of substrate topography and chemistry on human mesenchymal stem cell gene expression

Abstract:

Variations in substrate chemistry and the micro-structure were shown to have a significant effect on the biology of human mesenchymal stromal cells (hMSCs). This occurs when differences in the surface properties indirectly modulate pathways within numerous signaling networks that control cell fate. To understand how the surface features affect hMSC gene expression, we performed RNA-sequencing analysis of bone marrow-derived hMSCs cultured on tissue culture-treated polystyrene (TCP) and poly(l...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3390/ijms19082344

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Oxford college:
Kellogg College
Role:
Author
ORCID:
0000-0003-2537-1468
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Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Role:
Author
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China Regenerative Medicine International Limited, Hong Kong More from this funder
Publisher:
MDPI Publisher's website
Journal:
International Journal of Molecular Sciences Journal website
Volume:
19
Issue:
8
Article number:
2344
Publication date:
2018-08-09
Acceptance date:
2018-08-07
DOI:
ISSN:
1422-0067
Source identifiers:
897016
Language:
English
Keywords:
Pubs id:
pubs:897016
UUID:
uuid:3fef54c2-5181-45f5-9316-170f6502e8c0
Local pid:
pubs:897016
Deposit date:
2018-08-09

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