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Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci

Abstract:

Smoking is a major heritable and modifiable risk factor for many diseases, including cancer, common respiratory disorders and cardiovascular diseases. Fourteen genetic loci have previously been associated with smoking behaviour-related traits. We tested up to 235,116 single nucleotide variants (SNVs) on the exome-array for association with smoking initiation, cigarettes per day, pack-years, and smoking cessation in a fixed effects meta-analysis of up to 61 studies (up to 346,813 participants)...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41380-018-0313-0

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Publisher:
Springer Nature Publisher's website
Journal:
Molecular Psychiatry Journal website
Volume:
25
Pages:
2392–2409
Publication date:
2019-01-07
Acceptance date:
2018-11-14
DOI:
EISSN:
1476-5578
ISSN:
1359-4184
Pmid:
30617275
Source identifiers:
958837
Language:
English
Pubs id:
pubs:958837
UUID:
uuid:3fd26f8a-6d1e-44af-bb59-b6dac4a9d5d4
Local pid:
pubs:958837
Deposit date:
2019-01-21

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