Journal article
DNA polymerase conformational dynamics and the role of fidelity-conferring residues: Insights from computational simulations
- Abstract:
-
Herein we investigate the molecular bases of DNA polymerase I conformational dynamics that underlie the replication fidelity of the enzyme. Such fidelity is determined by conformational changes that promote the rejection of incorrect nucleotides before the chemical ligation step. We report a comprehensive atomic resolution study of wild type and mutant enzymes in different bound states and starting from different crystal structures, using extensive molecular dynamics (MD) simulations that cov...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- Frontiers Media Publisher's website
- Journal:
- Frontiers in Molecular Biosciences Journal website
- Volume:
- 3
- Issue:
- MAY
- Article number:
- 20
- Publication date:
- 2016-05-27
- Acceptance date:
- 2016-05-10
- DOI:
- EISSN:
-
2296-889X
- Pmid:
-
27303671
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:628301
- UUID:
-
uuid:3fb6a57f-fb1e-41a0-9c2b-4facc621c9df
- Local pid:
- pubs:628301
- Source identifiers:
-
628301
- Deposit date:
- 2019-02-07
Terms of use
- Copyright holder:
- Meli et al
- Copyright date:
- 2016
- Notes:
- Copyright © 2016 Meli et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Licence:
- CC Attribution (CC BY)
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