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Genetic variation underlying cognition and its relation with neurological outcomes and brain imaging

Abstract:

Cognition in adults shows variation due to developmental and degenerative components. A recent genome-wide association study identified genetic variants for general cognitive function in 148 independent loci. Here, we aimed to elucidate possible developmental and neurodegenerative pathways underlying these genetic variants by relating them to functional, clinical and neuroimaging outcomes. This study was conducted within the population-based Rotterdam Study (N=11,496, mean age 65.3±9.9 years,...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.18632/aging.101844

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Role:
Author
ORCID:
0000-0002-3597-1531
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Publisher:
Impact Journals Publisher's website
Journal:
Aging Journal website
Volume:
11
Issue:
5
Pages:
1440-1456
Publication date:
2019-03-04
Acceptance date:
2019-02-21
DOI:
EISSN:
1945-4589
Pmid:
30830859
Source identifiers:
986011
Language:
English
Keywords:
Pubs id:
pubs:986011
UUID:
uuid:3f6ff81a-355f-44b7-ba09-0aa01b51239b
Local pid:
pubs:986011
Deposit date:
2019-04-30

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