Thesis
Arylamine N-Acetyltransferases from mycobacteria: investigations of a potential yarget for anti-tubercular therapy
- Abstract:
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Reactivation of latent infection is the major cause of tuberculosis (TB). Cholesterol is a critical carbon source during latent infection. Catabolism of cholesterol contributes to the pool of propionyl-CoA, a precursor that is incorporated into cell-wall lipids.
Arylamine N-acetyltransferase (NAT) is encoded within a gene cluster that is involved in the sterol-ring degradation and is essential for intracellular survival. NAT from M. tuberculosis (TBNAT) can utilise propionyl-CoA and...
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Funding
Bibliographic Details
- Publication date:
- 2013
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
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uuid:3f571661-7b51-4fa8-bf5e-2adff9269c59
- Local pid:
- ora:7173
- Deposit date:
- 2013-08-09
Terms of use
- Copyright holder:
- Abuhammad, A
- Copyright date:
- 2013
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