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Arylamine N-Acetyltransferases from mycobacteria: investigations of a potential yarget for anti-tubercular therapy

Abstract:

Reactivation of latent infection is the major cause of tuberculosis (TB). Cholesterol is a critical carbon source during latent infection. Catabolism of cholesterol contributes to the pool of propionyl-CoA, a precursor that is incorporated into cell-wall lipids.

Arylamine N-acetyltransferase (NAT) is encoded within a gene cluster that is involved in the sterol-ring degradation and is essential for intracellular survival. NAT from M. tuberculosis (TBNAT) can utilise propionyl-CoA and...

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Research group:
E. Sim's Group
Oxford college:
University College
Role:
Author

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Role:
Supervisor
Role:
Supervisor
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Funding agency for:
Abuhammad, A
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:3f571661-7b51-4fa8-bf5e-2adff9269c59
Local pid:
ora:7173
Deposit date:
2013-08-09

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