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Journal article

CD103+ tumor-infiltrating lymphocytes are tumor-reactive intraepithelial CD8+ T cells associated with prognostic benefit and therapy response in cervical cancer.

Abstract:

Human papilloma virus (HPV)-induced cervical cancer constitutively expresses viral E6/E7 oncoproteins and is an excellent target for T cell-based immunotherapy. However, not all tumor-infiltrating T cells confer equal benefit to patients, with epithelial T cells being superior to stromal T cells. To assess whether the epithelial T cell biomarker CD103 could specifically discriminate the beneficial antitumor T cells, association of CD103 with clinicopathological variables and outcome was analy...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


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Dutch Cancer Society More from this funder
Jan Kornelis de Cock Stichting More from this funder
Academy of Medical Sciences More from this funder
Netherlands Organisation for Scientific Research More from this funder
Oxford Cancer Center More from this funder
Publisher:
Taylor and Francis Publisher's website
Journal:
Oncoimmunology Journal website
Volume:
6
Issue:
9
Pages:
e1338230
Publication date:
2017-07-01
Acceptance date:
2017-05-30
DOI:
EISSN:
2162-402X
ISSN:
2162-4011
Pmid:
28932636
Source identifiers:
730849
Language:
English
Keywords:
Pubs id:
pubs:730849
UUID:
uuid:3f2c5b6f-329b-49fb-a911-eef10dfcab0a
Local pid:
pubs:730849
Deposit date:
2017-10-13

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