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Journal article

Detecting intratumoral heterogeneity of EGFR activity by liposome-based in vivo transfection of a fluorescent biosensor.

Abstract:

Despite decades of research in the epidermal growth factor receptor (EGFR) signalling field, and many targeted anti-cancer drugs that have been tested clinically, the success rate for these agents in the clinic is low, particularly in terms of the improvement of overall survival. Intratumoral heterogeneity is proposed as a major mechanism underlying treatment failure of these molecule-targeted agents. Here we highlight the application of fluorescence lifetime microscopy (FLIM)-based biosensin...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0002-9041-1852
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Contributors

Sander, K
Medical Research Council More from this funder
UK Department of Health More from this funder
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Pmid:
28166195
Source identifiers:
679143
Language:
English
Keywords:
Pubs id:
pubs:679143
UUID:
uuid:3eda91f6-a25b-4bd4-bd4b-587a3809da2f
Local pid:
pubs:679143
Deposit date:
2018-02-02

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