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Thesis

The impact of cytomegalovirus infection and viral vector vaccination on human and mouse immune systems

Abstract:

Viral vectors are a next-generation vaccine platform that elicit a robust response from the humoral and cellular arms of the immune system. The importance of this vaccine platform was demonstrated during this PhD with the emergence of SARS-CoV-2 and the development of the chimpanzee adenovirus-vectored vaccine ChAdOx1 nCoV-19. Although this vaccine is immunogenic, pre-existing infections such as cytomegalovirus have been shown to reduce antigen-specific vaccine immunogenicity in other vacc...

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Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Oxford college:
St Edmund Hall
Role:
Author
ORCID:
https://orcid.org/ 0000-0002-1194-2429

Contributors

Division:
MSD
Department:
Paediatrics
Sub department:
Paediatrics
Research group:
Oxford Vaccine Group
Role:
Supervisor
ORCID:
0000-0001-7711-897X
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Supervisor
ORCID:
0000-0002-6823-9750
Division:
MSD
Department:
NDM
Research group:
Peter Medawar Building for Pathogen Research
Role:
Supervisor
ORCID:
0000-0003-4307-9161
More from this funder
Programme:
IITM DPhil Studentship
Funding agency for:
Sharpe, HR
Grant:
203805/Z/16/Z
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
Deposit date:
2022-01-05

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