Thesis
Evaluation of a novel biomarker as a predictor of response, stratification tool, and measure of pharmacology for a disease-modifying osteoarthritis therapeutic
- Abstract:
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Introduction
Osteoarthritis (OA) is a leading cause of disability in developed countries and is independently associated with increased mortality. Aggrecan degradation is an early process in OA-related cartilage degradation, principally attributed to activity of the aggrecanase ADAMTS-5. One of the products of this activity is ARGS neoepitope which is proposed as a biomarker of OA disease burden. Biomarker measurement and correlation could advance research into effective interventio...
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Authors
Contributors
+ Taylor, P
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Supervisor
+ Snelling, S
Role:
Supervisor
Bibliographic Details
- Type of award:
- MSc by Research
- Level of award:
- Masters
- Awarding institution:
- University of Oxford
Item Description
- UUID:
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uuid:3dfdc596-fcc0-4f8a-a60e-535282d5b25f
- Deposit date:
- 2016-05-03
Terms of use
- Copyright holder:
- Sprot, H
- Copyright date:
- 2016
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