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Development of recombinant Adeno-Associated Viral vector (rAAV) for passive immunisation against ebola

Abstract:

The 2014-2016 Ebola outbreak in West Africa was the largest in history leading to 28,639 cases, of which 40% were fatal. Better treatments and effective vaccines against Ebola virus are needed to prevent future recurrence. Multiple, novel, treatment options were assessed during the outbreak, including ZMapp™ monoclonal antibody therapy, which showed promising results in some patients. However, widespread adoption of this approach is hindered by high costs of monoclonal antibody manufacturing ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.ymthe.2017.04.025

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Clinical Laboratory Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM - Investigative Medicine Division
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Clinical Laboratory Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Oxford college:
University College
Role:
Author
Wellcome Trust More from this funder
Publisher:
Elsevier Publisher's website
Journal:
MOLECULAR THERAPY Journal website
Series:
Molecular Therapy
Host title:
American Society of Gene and Cell Therapy Annual Meeting (ASCGT 2017)
Publication date:
2017-05-04
Acceptance date:
2017-03-28
DOI:
Source identifiers:
717384
Pubs id:
pubs:717384
UUID:
uuid:3dcbec8c-3e81-46c2-857b-90ecee9b574b
Local pid:
pubs:717384
Deposit date:
2018-08-06

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