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Journal article

Parameters for reliable results in genetic association studies in common disease.

Abstract:
It is increasingly apparent that the identification of true genetic associations in common multifactorial disease will require studies comprising thousands rather than the hundreds of individuals employed to date. Using 2,873 families, we were unable to confirm a recently published association of the interleukin 12B gene in 422 type I diabetic families. These results emphasize the need for large datasets, small P values and independent replication if results are to be reliable.

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Publisher copy:
10.1038/ng825

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Journal:
Nature genetics
Volume:
30
Issue:
2
Pages:
149-150
Publication date:
2002-02-01
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Source identifiers:
176354
Language:
English
Keywords:
Pubs id:
pubs:176354
UUID:
uuid:3db0c332-3faa-4d39-ba64-cd7b9959d641
Local pid:
pubs:176354
Deposit date:
2012-12-19

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