Journal article
Inflation vs exhaustion of antiviral CD8+ t-cell populations in persistent infections: two sides of the same coin?
- Abstract:
-
Persistent virus infection can drive CD8+ T-cell responses which are markedly divergent in terms of frequency, phenotype, function, and distribution. On the one hand viruses such as Lymphocytic Choriomeningitis Virus (LCMV) Clone 13 can drive T-cell "exhaustion", associated with upregulation of checkpoint molecules, loss of effector functions, and diminished control of viral replication. On the other, low-level persistence of viruses such as Cytomegalovirus and Adenoviral vaccines can drive m...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Bibliographic Details
- Publisher:
- Frontiers Media Publisher's website
- Journal:
- Frontiers in Immunology Journal website
- Volume:
- 10
- Pages:
- 197
- Publication date:
- 2019-03-06
- Acceptance date:
- 2019-01-23
- DOI:
- ISSN:
-
1664-3224
- Pmid:
-
30894851
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:983974
- UUID:
-
uuid:3d0acfaa-016c-420f-8826-1fcc4fbeebc1
- Local pid:
- pubs:983974
- Deposit date:
- 2019-03-25
Terms of use
- Copyright holder:
- Marchi et al
- Copyright date:
- 2019
- Notes:
- © 2019 Marchi, Lee and Klenerman. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Licence:
- CC Attribution (CC BY)
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