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Liquid chromatography–tandem mass spectrometry for the simultaneous quantitation of ceftriaxone, metronidazole and hydroxymetronidazole in plasma from seriously ill, severely malnourished children

Abstract:

We have developed and validated a novel, sensitive, selective and reproducible reversed-phase high-performance liquid chromatography method coupled with electrospray ionization mass spectrometry (HPLC–ESI-MS/MS) for the simultaneous quantitation of ceftriaxone (CEF), metronidazole (MET) and hydroxymetronidazole (MET-OH) from only 50 μL of human plasma, and unbound CEF from 25 μL plasma ultra-filtrate to evaluate the effect of protein binding. Cefuroxime axetil (CEFU) was used as an internal s...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.12688/wellcomeopenres.11728.2

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Institution:
University of Oxford
Oxford college:
Nuffield College
Role:
Author
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National Institute for Health Research More from this funder
Estonian Research Council More from this funder
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Publisher:
Wellcome Trust Publisher's website
Journal:
Wellcome Open Research Journal website
Volume:
2
Pages:
43
Publication date:
2017-06-01
Acceptance date:
2017-06-19
DOI:
EISSN:
2398-502X
Source identifiers:
707819
Keywords:
Subjects:
Pubs id:
pubs:707819
UUID:
uuid:3d020626-f73c-4113-a914-d0540861a86e
Local pid:
pubs:707819
Deposit date:
2017-07-12

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