Journal article
Liquid chromatography–tandem mass spectrometry for the simultaneous quantitation of ceftriaxone, metronidazole and hydroxymetronidazole in plasma from seriously ill, severely malnourished children
- Abstract:
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We have developed and validated a novel, sensitive, selective and reproducible reversed-phase high-performance liquid chromatography method coupled with electrospray ionization mass spectrometry (HPLC–ESI-MS/MS) for the simultaneous quantitation of ceftriaxone (CEF), metronidazole (MET) and hydroxymetronidazole (MET-OH) from only 50 μL of human plasma, and unbound CEF from 25 μL plasma ultra-filtrate to evaluate the effect of protein binding. Cefuroxime axetil (CEFU) was used as an internal s...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.5MB)
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- Publisher copy:
- 10.12688/wellcomeopenres.11728.2
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Authors
Funding
National Institute for Health Research
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Estonian Research Council
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Bibliographic Details
- Publisher:
- Wellcome Trust Publisher's website
- Journal:
- Wellcome Open Research Journal website
- Volume:
- 2
- Pages:
- 43
- Publication date:
- 2017-06-01
- Acceptance date:
- 2017-06-19
- DOI:
- EISSN:
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2398-502X
- Source identifiers:
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707819
Item Description
Terms of use
- Copyright holder:
- Ongas et al
- Copyright date:
- 2017
- Notes:
- © 2017 Ongas M et al. This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The author(s) is/are employees of the US Government and therefore domestic copyright protection in USA does not apply to this work. The work may be protected under the copyright laws of other jurisdictions when used in those jurisdictions.
- Licence:
- CC Attribution (CC BY)
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