Journal article icon

Journal article

Whole brain and regional hyperintense white matter volume and blood pressure: overlap of genetic loci produced by bivariate, whole-genome linkage analyses

Abstract:

Background and Purpose— The volume of T2-hyperintense white matter (HWM) is an important neuroimaging marker of cerebral integrity with a demonstrated high heritability. Pathophysiology studies have shown that the regional, ependymal, and subcortical HWM lesions are associated with elevated arterial pulse pressure and arterial blood pressure (BP), respectively. We performed bivariate, whole-genome linkage analyses for HWM volumes and BP measurements to identify chromosomal...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Expand authors...
Publisher:
American Heart Association Publisher's website
Journal:
Stroke Journal website
Volume:
41
Issue:
10
Pages:
2137-2142
Publication date:
2010-10-01
DOI:
EISSN:
1524-4628
ISSN:
0039-2499
Source identifiers:
445988
Language:
English
Keywords:
Subjects:
Pubs id:
pubs:445988
UUID:
uuid:3bdb2da2-ab5a-49a0-abb0-dc77779968da
Local pid:
pubs:445988
Deposit date:
2014-01-18

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP