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Journal article

Human genetic resistance to malaria.

Abstract:

This brief chapter highlights the need for caution when designing and interpreting studies aimed at seeking new genes that may be associated with malaria protection, or investigating the potential mechanisms for protection in promising candidates. Judging genetic effects on the basis of the wrong clinical phenotype and missing true protective genes because their protective effects are masked by unpredictable epistatic effects are major potential pitfalls. These issues are by no means unique t...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
Kilifi District Hospital, Kilifi, Kenya
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Role:
Author

Contributors

Institution:
University of Bristol
Role:
Editor
Institution:
University of Melbourne
Role:
Editor
Institution:
University of Oxford
Role:
Editor
European Network 6 BioMalpar Consortium More from this funder
Wellcome Trust More from this funder
INDEPTH Network More from this funder
Publisher:
Springer New York Publisher's website
Journal:
Advances in experimental medicine and biology Journal website
Volume:
634
Pages:
243-253
Publication date:
2009-01-01
DOI:
ISSN:
0065-2598
Source identifiers:
34643
Language:
English
Keywords:
Subjects:
UUID:
uuid:3b151332-dc7a-4a13-9f86-59b8e4a9d6b7
Local pid:
pubs:34643
Deposit date:
2012-12-19

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