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A phenome-wide association study of a lipoprotein associated phospholipase A2 loss-of-function variant in 90 000 Chinese adults

Abstract:

Background

Lipoprotein-associated phospholipase A2 (Lp-PLA2) has been implicated in development of atherosclerosis, however, recent randomised trials of Lp-PLA2 inhibition reported no beneficial effects on vascular diseases. In East Asians, a loss-of-function variant in the PLA2G7 gene can be used to assess the effects of genetically-determined lower Lp-PLA2.

Methods

PLA2G7V279F (rs76863441) was genotyped in 91 428 individuals randomly-selected from the China Kadoo...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/ije/dyw087

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
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Kadoorie Charitable Foundation Hong Kong More from this funder
Merck Sharp and Dohme Corp More from this funder
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Publisher:
Oxford University Press Publisher's website
Journal:
International Journal of Epidemiology Journal website
Publication date:
2016-06-01
DOI:
ISSN:
1464-3685
Source identifiers:
614462
Keywords:
Pubs id:
pubs:614462
UUID:
uuid:3adbcb53-7e2f-4c8b-ae58-45328629a030
Local pid:
pubs:614462
Deposit date:
2016-04-08

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