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DP2 antagonism reduces airway smooth muscle mass in asthma by decreasing eosinophilia and myofibroblast recruitment

Abstract:

Increased airway smooth muscle mass, a feature of airway remodeling in asthma, is the strongest predictor of airflow limitation and contributes to asthma-associated morbidity and mortality. No current drug therapy for asthma is known to affect airway smooth muscle mass. Although there is increasing evidence that prostaglandin D2 type 2 receptor (DP2) is expressed in airway structural and inflammatory cells, few studies have addressed the expression and function of DP2 in airway smooth muscle ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0001-8893-6687
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Role:
Author
ORCID:
0000-0003-1586-7486
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Role:
Author
ORCID:
0000-0002-4531-3540
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Publisher:
American Association for the Advancement of Science Publisher's website
Journal:
Science Translational Medicine Journal website
Volume:
11
Issue:
479
Article number:
eaao6451
Publication date:
2019-02-13
Acceptance date:
2019-01-25
DOI:
EISSN:
1946-6242
ISSN:
1946-6234
Pmid:
30760581
Source identifiers:
975967
Language:
English
Keywords:
Pubs id:
pubs:975967
UUID:
uuid:3a7d7410-80cf-4161-a41d-1a0587338ec4
Local pid:
pubs:975967
Deposit date:
2019-06-24

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