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Thesis

Genetic susceptibility to endometrial cancer

Abstract:

Endometrial cancer (EC) is the fourth most common cancer affecting women in the UK. Those with a family history of EC have an increased risk compared with the general population. Highly penetrant germline mutations in mismatch repair (MMR) genes and DNA polymerases account for only a small proportion of the familial aggregation.

The aim of this thesis is to investigate the genetic susceptibility to EC in the general population using cases and controls of European ancestry. A GWAS me...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Oxford college:
Pembroke College
Role:
Author

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Role:
Supervisor
Publication date:
2015
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:3a559ae0-156f-48a2-a64e-b03a13c562df
Local pid:
ora:11936
Deposit date:
2015-07-28

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