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Thesis

The role of CRTH2+ CD8+ T cells in severe asthma

Abstract:

Type 2 inflammation of the airways is present in most patients with asthma, and some patients with chronic obstructive pulmonary disease (COPD). The molecular drivers of the type 2 immune response include the cytokines IL-4, IL-5, and IL-13, produced by activated type 2 T helper (Th2) and type 2 cytotoxic T (Tc2) cells. Expression of the prostaglandin D2 (PGD2) receptor chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) has been associated wit...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Oxford college:
Magdalen College
Role:
Author
ORCID:
0000-0001-9084-962X

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Oxford college:
New College
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Oxford college:
Green Templeton College
Role:
Supervisor
ORCID:
0000-0003-4307-9161
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Oxford college:
St Edmund Hall
Role:
Supervisor
Institution:
Faculty of Medicine at the National Heart & Lung Institute, Imperial College London
Role:
Examiner
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More from this funder
Programme:
Oxford MRC DTP – Magdalen-RCUK - NDM Prize Studentship
Grant:
BRT00030
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
Deposit date:
2022-01-17

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