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Characterization of pathogenic monoclonal autoantibodies derived from muscle-specific kinase myasthenia gravis patients

Abstract:

Myasthenia gravis (MG) is a chronic autoimmune disorder characterized by muscle weakness and caused by pathogenic autoantibodies that bind to membrane proteins at the neuromuscular junction. Most patients have autoantibodies against the acetylcholine receptor (AChR), but a subset of patients have autoantibodies against muscle-specific tyrosine kinase (MuSK) instead. MuSK is an essential component of the pathway responsible for synaptic differentiation, which is activated by nerve-released agr...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1172/jci.insight.127167

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
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Publisher:
American Society for Clinical Investigation Publisher's website
Journal:
JCI Insight Journal website
Volume:
4
Issue:
12
Article number:
e127167
Publication date:
2019-06-20
Acceptance date:
2019-05-10
DOI:
ISSN:
2379-3708
Source identifiers:
998774
Keywords:
Pubs id:
pubs:998774
UUID:
uuid:39f29e9c-363f-4fa6-9711-bc766f4a8fb8
Local pid:
pubs:998774
Deposit date:
2019-05-15

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