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Biphasic voltage‐dependent inactivation of human NaV1.3, 1.6 and 1.7 Na+ channels expressed in rodent insulin‐secreting cells

Abstract:

Pancreatic β-cells are equipped with voltage-gated Na+ channels that undergo biphasic voltage-dependent steady-state inactivation. A small Na+ current component (10-15%) inactivates over physiological membrane potentials and contributes to action potential firing. However, the major Na+ channel component is completely inactivated at -90 to -80 mV and is therefore inactive in the β-cell. It has been proposed that the biphasic inactivation reflects the contribution of different NaV α-subunits. ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1113/jp275587

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; OCDEM
Role:
Author
ORCID:
0000-0002-3626-4855
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Oxford college:
Harris Manchester College
Role:
Author
ORCID:
0000-0001-7578-0767
More from this funder
Funding agency for:
Zhang, Q
Grant:
RD Lawrence Fellow
More from this funder
Funding agency for:
Rorsman, P
Grant:
Senior Investigator Award
Publisher:
Physiological Society Publisher's website
Journal:
Journal of Physiology Journal website
Volume:
596
Issue:
9
Pages:
1601-1626
Publication date:
2018-03-30
Acceptance date:
2018-02-06
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
Pmid:
29441586
Source identifiers:
824933
Language:
English
Keywords:
Pubs id:
pubs:824933
UUID:
uuid:3962dfd3-41af-4641-9db1-70a5ee42e3c6
Local pid:
pubs:824933
Deposit date:
2018-04-04

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