Biphasic voltage‐dependent inactivation of human NaV1.3, 1.6 and 1.7 Na+ channels expressed in rodent insulin‐secreting cells
Pancreatic β-cells are equipped with voltage-gated Na+ channels that undergo biphasic voltage-dependent steady-state inactivation. A small Na+ current component (10-15%) inactivates over physiological membrane potentials and contributes to action potential firing. However, the major Na+ channel component is completely inactivated at -90 to -80 mV and is therefore inactive in the β-cell. It has been proposed that the biphasic inactivation reflects the contribution of different NaV α-subunits. ...Expand abstract
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- Godazgar et al
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