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Use of trifluoroacetaldehyde N-tfsylhydrazone as a trifluorodiazoethane surrogate and its synthetic applications

Abstract:

Trifluorodiazoethane (CF3CHN2), a highly reactive fluoroalkylating reagent, offers a useful means to introduce trifluoromethyl groups into organic molecules. At present, CF3CHN2 can only be generated by oxidation of trifluoroethylamine hydrochloride under acidic conditions; due to its toxic and explosive nature, its safe generation and use remains a prominent concern, hampering wider synthetic exploitation. Here we report the development of trifluoroacetaldehyde N-tfsylhydrazone (TFHZ-Tfs) as...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-018-08253-z

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Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
10
Article number:
284
Publication date:
2019-01-17
Acceptance date:
2018-12-19
DOI:
EISSN:
2041-1723
ISSN:
2041-1723
Pmid:
30655536
Source identifiers:
965592
Language:
English
Pubs id:
pubs:965592
UUID:
uuid:39111a1a-c638-49a9-9efc-79283e5d431b
Local pid:
pubs:965592
Deposit date:
2019-02-18

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