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Diagnosis of SARS-CoV-2 infection with LamPORE, a high-throughput platform combining loop-mediated isothermal amplification and nanopore sequencing

Abstract:

LamPORE is a novel diagnostic platform for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA combining loop-mediated isothermal amplification with nanopore sequencing, which could potentially be used to analyze thousands of samples per day on a single instrument. We evaluated the performance of LamPORE against reverse transcriptase PCR (RT-PCR) using RNA extracted from spiked respiratory samples and stored nose and throat swabs collected at two UK hospitals. Th...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/jcm.03271-20

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
ORCID:
0000-0002-4100-2163
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Role:
Author
ORCID:
0000-0001-6051-8985
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Publisher:
American Society for Microbiology Publisher's website
Journal:
Journal of Clinical Microbiology Journal website
Volume:
59
Issue:
6
Article number:
e03271-20
Publication date:
2021-03-29
Acceptance date:
2021-03-23
DOI:
EISSN:
1098-660X
ISSN:
0095-1137
Pmid:
33782112
Language:
English
Keywords:
Pubs id:
1170075
Local pid:
pubs:1170075
Deposit date:
2021-05-31

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