Non-specific effects of vaccines: plausible and potentially important, but implications uncertain.
Non-specific effects (NSE) or heterologous effects of vaccines are proposed to explain observations in some studies that certain vaccines have an impact beyond the direct protection against infection with the specific pathogen for which the vaccines were designed. The importance and implications of such effects remain controversial. There are several known immunological mechanisms which could lead to NSE, since it is widely recognised that the generation of specific immunity is initiated by n...Expand abstract
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- Peer review status:
- Peer reviewed
(Accepted manuscript, pdf, 170.8KB)
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- Pollard et al
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- © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
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