Journal article
The road to avibactam: The first clinically useful non-β-lactam working somewhat like a β-lactam
- Abstract:
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Avibactam, which is the first non-β-lactam β-lactamase inhibitor to be introduced for clinical use, is a broad-spectrum serine β-lactamase inhibitor with activity against class A, class C, and, some, class D β-lactamases. We provide an overview of efforts, which extend to the period soon after the discovery of the penicillins, to develop clinically useful non-β-lactam compounds as antibacterials, and, subsequently, penicillin-binding protein and β-lactamase inhibitors. Like the β-lactam inhib...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 16.1MB)
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- Publisher copy:
- 10.4155/fmc-2016-0078
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Authors
Funding
Biotechnology and Biological Sciences Research Council
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Biochemical Society
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AstraZeneca,
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Bibliographic Details
- Publisher:
- Future Science Ltd Publisher's website
- Journal:
- Future Medicinal Chemistry Journal website
- Volume:
- 8
- Issue:
- 10
- Pages:
- 1063-1084
- Publication date:
- 2016-06-01
- Acceptance date:
- 2016-05-06
- DOI:
- EISSN:
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1756-8927
- ISSN:
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1756-8919
- Source identifiers:
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631143
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:631143
- UUID:
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uuid:387bb618-ff2e-4cbb-adc2-d38cb9d37ac6
- Local pid:
- pubs:631143
- Deposit date:
- 2016-08-16
Terms of use
- Copyright holder:
- Wang D Y et al
- Copyright date:
- 2016
- Notes:
- This article is distributed under the terms of the Creative Commons Attribution License 4.0 which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. To view a copy of the license, visit http://creativecommons.org/licenses/by/4.0/
- Licence:
- CC Attribution (CC BY)
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