Journal article
Single arm two‐stage studies: Improved designs for molecularly targeted agents
- Abstract:
-
Mechanistic understanding of cancers and their potential interactions withmolecularly targeted agents is driving the need for stratified medicine to ensureeach participant receives the best possible care. This understanding, backed byscientific research , should be used to guide the design of clinical trials for theseagents. The mechanism of action of a molecularly targeted agent often suggeststhat a biomarker can be used as a predictor of activity of the agent on thetargeted disease. A bioma...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- Pharmaceutical Statistics Journal website
- Volume:
- 17
- Issue:
- 6
- Pages:
- 761-769
- Publication date:
- 2018-08-15
- Acceptance date:
- 2018-06-26
- DOI:
- EISSN:
-
1539-1612
- ISSN:
-
1539-1604
- Pmid:
-
30112838
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:892005
- UUID:
-
uuid:380ac733-8bfd-4f92-a844-40be73bb1e6b
- Local pid:
- pubs:892005
- Source identifiers:
-
892005
- Deposit date:
- 2018-10-11
Terms of use
- Copyright holder:
- Wiley
- Copyright date:
- 2018
- Notes:
- © 2018 John Wiley and Sons, Ltd. This is the accepted manuscript version of the article. The final version is available online from Wiley at: https://doi.org/10.1002/pst.1896
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