Journal article icon

Journal article

Single arm two‐stage studies: Improved designs for molecularly targeted agents

Abstract:

Mechanistic understanding of cancers and their potential interactions withmolecularly targeted agents is driving the need for stratified medicine to ensureeach participant receives the best possible care. This understanding, backed byscientific research , should be used to guide the design of clinical trials for theseagents. The mechanism of action of a molecularly targeted agent often suggeststhat a biomarker can be used as a predictor of activity of the agent on thetargeted disease. A bioma...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1002/pst.1896

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Role:
Author
ORCID:
0000-0003-1741-5467
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Centre for Statistics in Medicine
Oxford college:
St Cross College
Role:
Author
ORCID:
0000-0001-7123-0004
Publisher:
Wiley Publisher's website
Journal:
Pharmaceutical Statistics Journal website
Volume:
17
Issue:
6
Pages:
761-769
Publication date:
2018-08-15
Acceptance date:
2018-06-26
DOI:
EISSN:
1539-1612
ISSN:
1539-1604
Pmid:
30112838
Source identifiers:
892005
Language:
English
Keywords:
Pubs id:
pubs:892005
UUID:
uuid:380ac733-8bfd-4f92-a844-40be73bb1e6b
Local pid:
pubs:892005
Deposit date:
2018-10-11

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP