Thesis
Olefin metathesis for site-selective protein modification
- Abstract:
-
Site-selective protein modification has become an important tool to study protein functions in chemical biology. In the preliminary work, allyl sulfides were found to be reactive substrates in aqueous cross-metathesis (CM) enabling the first examples of protein modification via this approach. In order to access the enhanced CM reactivity of allyl sulfide on proteins, facile chemical methods to install S-allyl cysteine on protein surface were developed. In particular, a cysteine-specific al...
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Bibliographic Details
- Publication date:
- 2013
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:37d998f6-c1cd-4e2c-9f9f-89d197d21016
- Local pid:
- ora:7134
- Deposit date:
- 2013-08-02
Terms of use
- Copyright holder:
- Lin, Y
- Copyright date:
- 2013
- Notes:
- This thesis is not currently available in ORA.
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