Journal article
Genome-wide methylation profiling in Crohn's disease identifies altered epigenetic regulation of key host defense mechanisms including the Th17 pathway
- Abstract:
-
Background Germline variation in the 71 Crohn's disease (CD) loci implicated by genome-wide association studies (GWAS) only accounts for approximately 25% of estimated heritability. The contribution of epigenetic alterations to disease pathogenesis is emerging as a research priority. Materials and Methods: The methylation status of 27,578 CpG sites across the genome was analyzed using the Illumina Human Methylation27 assay in DNA extracted from whole blood samples from 40 adult females (21 il...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1002/ibd.21912
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Authors
Funding
Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Inflammatory Bowel Diseases Journal website
- Volume:
- 18
- Issue:
- 5
- Pages:
- 889-899
- Publication date:
- 2011-10-21
- Acceptance date:
- 2011-09-08
- DOI:
- EISSN:
-
1536-4844
- ISSN:
-
1078-0998
- Pmid:
-
22021194
- Source identifiers:
-
827886
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:827886
- UUID:
-
uuid:37545460-52e5-4d27-993e-73271d8d2962
- Local pid:
- pubs:827886
- Deposit date:
- 2018-08-09
Terms of use
- Copyright holder:
- Crohn’s and Colitis Foundation of America
- Copyright date:
- 2011
- Notes:
-
Copyright © 2011 Crohn’s & Colitis Foundation of America, Inc.
.
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