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Genome-wide methylation profiling in Crohn's disease identifies altered epigenetic regulation of key host defense mechanisms including the Th17 pathway

Abstract:

Background Germline variation in the 71 Crohn's disease (CD) loci implicated by genome-wide association studies (GWAS) only accounts for approximately 25% of estimated heritability. The contribution of epigenetic alterations to disease pathogenesis is emerging as a research priority. Materials and Methods: The methylation status of 27,578 CpG sites across the genome was analyzed using the Illumina Human Methylation27 assay in DNA extracted from whole blood samples from 40 adult females (21 il...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/ibd.21912

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Role:
Author
ORCID:
0000-0001-8916-018X
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Role:
Author
ORCID:
0000-0003-4368-1961
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Role:
Author
ORCID:
0000-0003-3634-6428
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Publisher:
Oxford University Press Publisher's website
Journal:
Inflammatory Bowel Diseases Journal website
Volume:
18
Issue:
5
Pages:
889-899
Publication date:
2011-10-21
Acceptance date:
2011-09-08
DOI:
EISSN:
1536-4844
ISSN:
1078-0998
Pmid:
22021194
Source identifiers:
827886
Language:
English
Keywords:
Pubs id:
pubs:827886
UUID:
uuid:37545460-52e5-4d27-993e-73271d8d2962
Local pid:
pubs:827886
Deposit date:
2018-08-09

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