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Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness

Abstract:

Hand grip strength is a widely used proxy of muscular fitness, a marker of frailty, and predictor of a range of morbidities and all-cause mortality. To investigate the genetic determinants of variation in grip strength, we perform a large-scale genetic discovery analysis in a combined sample of 195,180 individuals and identify 16 loci associated with grip strength (P < 5 × 10 -8 ) in combined analyses. A number of these loci contain genes implicated in structure and function of skeletal m...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ncomms16015

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More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Big Data Institute
Role:
Author
More by this author
Institution:
University of Oxford
Oxford college:
Green Templeton College
Role:
Author
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
8
Issue:
16015
Pages:
1-12
Publication date:
2017-07-12
Acceptance date:
2017-05-22
DOI:
ISSN:
2041-1723
Source identifiers:
709499
Keywords:
Pubs id:
pubs:709499
UUID:
uuid:36bb7f1a-32b7-40d7-b9ef-7aada473b4ff
Local pid:
pubs:709499
Deposit date:
2017-08-05

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