Journal article
Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use
- Abstract:
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BACKGROUND:Smoking and alcohol use have been associated with common genetic variants in multiple loci. Rare variants within these loci hold promise in the identification of biological mechanisms in substance use. Exome arrays and genotype imputation can now efficiently genotype rare nonsynonymous and loss of function variants. Such variants are expected to have deleterious functional consequences and to contribute to disease risk. METHODS:We analyzed ∼250,000 rare variants from 16 independent...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
-
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(Accepted manuscript, pdf, 300.7KB)
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(Accepted manuscript, pdf, 555.6KB)
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- Publisher copy:
- 10.1016/j.biopsych.2018.11.024
Authors
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Biological Psychiatry Journal website
- Volume:
- 85
- Issue:
- 11
- Pages:
- 946-955
- Publication date:
- 2018-12-06
- Acceptance date:
- 2018-11-28
- DOI:
- ISSN:
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0006-3223 and 1873-2402
- Pmid:
-
30679032
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:966711
- UUID:
-
uuid:36af498b-bb44-45ce-8232-51c90d7c24ad
- Local pid:
- pubs:966711
- Source identifiers:
-
966711
- Deposit date:
- 2019-04-26
Terms of use
- Copyright holder:
- Society of Biological Psychiatry
- Copyright date:
- 2018
- Notes:
- © 2018 Society of Biological Psychiatry. This is the accepted manuscript version of the article. The final version is available online from the Society of Biological Psychiatry at: 10.1016/j.biopsych.2018.11.024
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