High resolution nuclear magnetic resonance studies of kringle containing proteins
The kringle is a name given to a sequence of seventy nine residues linked by three disulphide bridges, multiple copies of which have been found in a number of proteins involved in haemostasis. Kringles from plasminogen and prothrombin have been studied using high resolution nuclear magnetic resonance (NMR) spectroscopy.
Preliminary experiments demonstrated the kringles to be globular proteins in aqueous solution having well defined tertiary folds. Resonances have been assigned in th...Expand abstract
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- University of Oxford
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- Pluck, Nigel. D.
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- The digital copy of this thesis has been made available thanks to the generosity of Dr Leonard Polonsky
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